Anthony Joshua missed out on the chance to become a three-time heavyweight world champion after he was stopped by British rival Daniel Dubois in the fifth round.
Dubois, 27, knocked down Joshua towards the end of the opening round with an overhand right to the 34-year-old’s chin.
The IBF heavyweight champion then dropped Joshua at the end of round three and twice in the fourth.
A right hook ended the fight with a knockout for Dubois’ first defence of the title.
The fighters went toe to toe at London’s Wembley Stadium in front of a record 96,000 fans.